Digex

Pronunciation: a-mah-LASE/LYE-pase/PRO-tee-ase/SEL-ue-lase/HYE-oh-SYE-a-meen/fen-il-tole-OX-a-meen
Generic Name: Amylase/Lipase/Protease/Cellulase/Hyoscyamine/Phenyltoloxamine
Brand Name: Examples include Digex and Gastrinex

Digex is used for:

Relieving symptoms of indigestion (eg, feeling of fullness, gas, bloating) that occur after meals.

Digex is a digestive enzyme and anticholinergic combination. It works by helping the body to digest protein, starch, and fat. It also decreases bowel spasms.

Do NOT use Digex if:

• you are allergic to any ingredient in Digex or to pork protein


• you have inflammation of the pancreas (pancreatitis) or a flare-up of long-term pancreas problems


• you have severe esophagus problems (eg, irritation, narrowing); a blockage of the stomach, bowel, or bladder; bowel motility problems; or severe bowel problems (eg, severe ulcerative colitis, toxic megacolon)


• you have glaucoma, myasthenia gravis, or heart problems caused by severe bleeding

Contact your doctor or health care provider right away if any of these apply to you.

Before using Digex:

Some medical conditions may interact with Digex. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding


• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement


• if you have allergies to medicines, foods, or other substances


• if you have a history of pancreas problems, stomach or bowel problems (eg, blockage, short bowel syndrome), or cystic fibrosis


• if you have nerve problems, prostate problems, esophagus problems (eg, reflux), heart or blood vessel problems (eg, fast or irregular heartbeat, heart failure, coronary heart disease), hiatal hernia, kidney problems, an overactive thyroid, high blood pressure, urinary problems, paralysis, or brain damage, or if you are at risk for glaucoma


• if you have diarrhea or fever, have been very ill, or are in poor health

Some MEDICINES MAY INTERACT with Digex. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Amantadine, antihistamines (eg, diphenhydramine), haloperidol, monoamine oxidase inhibitors (MAOIs) (eg, phenelzine), other anticholinergics (eg, scopolamine), phenothiazines (eg, thioridazine), or tricyclic antidepressants (eg, amitriptyline) because they may increase the risk of Digex's side effects


• Narcotic pain medicines (eg, codeine) or potassium chloride because the risk of their side effects may be increased by Digex


• Ketoconazole or metoclopramide because their effectiveness may be decreased by Digex

This may not be a complete list of all interactions that may occur. Ask your health care provider if Digex may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Digex:

Use Digex as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Take Digex by mouth with each meal or snack as directed by your doctor.


• If you miss a dose of Digex, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once or take a dose without a snack or a meal.

Ask your health care provider any questions you may have about how to use Digex.

Important safety information:

• Digex may cause drowsiness, dizziness, blurred vision, or lightheadedness. These effects may be worse if you take it with alcohol or certain medicines. Use Digex with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.


• Check with your doctor before you drink alcohol or use medicines that may cause drowsiness (eg, sleep aids, muscle relaxers) while you are using Digex; it may add to their effects. Ask your pharmacist if you have questions about which medicines may cause drowsiness.


• Do NOT take more than the recommended dose or use for longer than prescribed without checking with your doctor.


• If you open the capsule, do not breathe in the powder. Some patients may experience an asthma attack or severe allergic reaction (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue) from breathing in the powder.


• Do not become overheated or dehydrated in hot weather or while you are being active; heatstroke may occur.


• Drink plenty of fluids, maintain good oral hygiene, and suck on sugarless hard candy to relieve dry mouth.


• Proper dental care is important while you are taking Digex. Brush and floss your teeth and visit the dentist regularly.


• Digex may make your eyes more sensitive to sunlight. It may help to wear sunglasses.


• Tell your doctor or dentist that you take Digex before you receive any medical or dental care, emergency care, or surgery.


• Contact your doctor if you have loose stools while you take Digex. Your doctor may need to decrease your dose.


• Use Digex with caution in the ELDERLY; they may be more sensitive to its effects, especially constipation, trouble urinating, dry mouth, drowsiness, agitation, confusion, excitability, or memory problems.


• Caution is advised when using Digex in CHILDREN; they may be more sensitive to its effects, especially excitability.


• PREGNANCY and BREAST-FEEDING: It is not known if Digex can cause harm to the fetus. If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Digex while you are pregnant. Digex is found in breast milk. If you are or will be breast-feeding while you use Digex, check with your doctor. Discuss any possible risks to your baby.

Possible side effects of Digex:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Blurred vision; constipation; decreased sweating; dizziness; drowsiness; dry mouth; enlarged pupils; excitability; headache; nausea; nervousness; trouble sleeping; weakness.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); agitation; behavior changes; confusion; decreased sexual ability; difficulty focusing eyes; disorientation; exaggerated sense of well-being; fast or irregular heartbeat; hallucinations; loss of consciousness; loss of coordination; memory loss; mental or mood changes; severe or persistent loose stools or diarrhea; severe or persistent stomach pain; severe or persistent trouble sleeping; speech changes; taste changes or loss; trouble urinating; unusual tiredness or weakness; vision changes; vomiting.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

See also: Digex side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include diarrhea; disorientation; excessive thirst or excitability; fever; hot, dry skin; seizures; severe dry mouth; severe or persistent blurred vision, dizziness, headache, nausea, or vomiting; trouble breathing or swallowing.

Proper storage of Digex:

Store Digex at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Digex out of the reach of children and away from pets.

General information:

• If you have any questions about Digex, please talk with your doctor, pharmacist, or other health care provider.


• Digex is to be used only by the patient for whom it is prescribed. Do not share it with other people.


• If your symptoms do not improve or if they become worse, check with your doctor.


• Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Digex. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

More Digex resources

• Digex Side Effects (in more detail)
• Digex Use in Pregnancy & Breastfeeding
• Digex Drug Interactions
• Digex Support Group
• 0 Reviews for Digex - Add your own review/rating

Compare Digex with other medications

• Functional Gastric Disorder

Digoxin Capsules

Pronunciation: di-JOX-in
Generic Name: Digoxin
Brand Name: Examples include Digitek and Lanoxin

Digoxin Capsules is used for:

Treating heart failure or slowing the heart rate in patients with chronic atrial fibrillation, a type of abnormal heart rhythm. It may also be used for other conditions as determined by your doctor.

Digoxin Capsules is a digitalis glycoside. It works by increasing the force of contraction of the heart and slowing heart rate.

Do NOT use Digoxin Capsules if:

• you are allergic to any ingredient in Digoxin Capsules


• you are currently taking sucralfate


• you have certain types of heart rhythm problems, such as ventricular fibrillation

Contact your doctor or health care provider right away if any of these apply to you.

Before using Digoxin Capsules:

Some medical conditions may interact with Digoxin Capsules. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding


• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement


• if you have allergies to medicines, foods, or other substances


• if you have severe heart failure or other heart problems (eg, inflammation, heart block, cor pulmonale, cardiomyopathy, amyloid heart disease ), extra heart beats (premature ventricular contractions [PVCs]), other types of abnormal heart rhythm, heart problems due to low thiamine (eg, beriberi heart disease), Wolff-Parkinson-White syndrome, heart blood vessel problems, or fainting due to a heart problem


• if you have severe kidney, liver or lung problems, or thyroid problems


• if you have low blood levels of calcium, magnesium, or potassium, or high blood levels of potassium or calcium


• if you have had a recent heart attack

Some MEDICINES MAY INTERACT with Digoxin Capsules. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Alprazolam, amiodarone, amphotericin B, anticholinergics (eg, propantheline), beta-blockers (eg, propranolol, carvedilol), bupivacaine, calcium, cyclosporine, diltiazem, diphenoxylate, diuretics (eg, hydrochlorothiazide, furosemide), indomethacin, itraconazole, macrolides (eg, erythromycin), propafenone, quinidine, quinine, spironolactone, stimulants (eg, amphetamine), succinylcholine, sympathomimetics (eg, albuterol, pseudoephedrine), tetracyclines (eg, doxycycline), thioamines (eg, methimazole), or verapamil because they may increase the risk of Digoxin Capsules's side effects, especially on the heart


• Spironolactone because it may interfere with certain lab tests for digoxin blood levels and give false readings


• Oral aminoglycosides (eg, neomycin) because the actions and the risk of side effects of Digoxin Capsules may be increased or decreased


• Acarbose, certain anticancer medicines, cholestyramine, colestipol, kaolin-pectin, metoclopramide, penicillamine, rifampin, sulfasalazine, or thyroid hormones (eg, levothyroxine) because they may decrease Digoxin Capsules's effectiveness

This may not be a complete list of all interactions that may occur. Ask your health care provider if Digoxin Capsules may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Digoxin Capsules:

Use Digoxin Capsules as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Take Digoxin Capsules by mouth. Do not take it within 1 hour of food high in fiber.


• Do not take antacids containing aluminum or magnesium, cholestyramine, or colestipol within 2 to 4 hours of taking Digoxin Capsules.


• If you miss a dose of Digoxin Capsules, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Digoxin Capsules.

Important safety information:

• Digoxin Capsules may cause dizziness or blurred vision. These effects may be worse if you take it with alcohol or certain medicines. Use Digoxin Capsules with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.


• Tell your doctor or dentist that you take Digoxin Capsules before you receive any medical or dental care, emergency care, or surgery.


• Digoxin Capsules may interfere with certain lab tests, including an electrocardiogram (ECG). Be sure your doctor and lab personnel know you are using Digoxin Capsules.


• Lab tests, including electrocardiogram (ECG), electrolytes, kidney function, and blood digoxin levels, may be performed while you use Digoxin Capsules. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.


• Use Digoxin Capsules with caution in the ELDERLY; they may be more sensitive to its effects.


• Use Digoxin Capsules with extreme caution in NEWBORNS OR NEWBORN INFANTS, especially those who are premature or immature; they may be more sensitive to its effects.


• Poisoning may occur in CHILDREN who accidently swallow Digoxin Capsules or receive too much medicine. In case of an overdose, call a doctor or poison control center right away.


• PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Digoxin Capsules while you are pregnant. Digoxin Capsules is found in breast milk. If you are or will be breast-feeding while you use Digoxin Capsules, check with your doctor. Discuss any possible risks to your baby.

Possible side effects of Digoxin Capsules:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Diarrhea; nausea.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); blurred vision, yellow vision, or other vision changes; confusion; fast, slow, or irregular heartbeat; hallucinations; mood or mental changes (eg, depression); severe or persistent nausea, vomiting, or stomach pain; unusual bruising or bleeding; unusual tiredness or weakness.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include very fast, very slow, or irregular heartbeat.

Proper storage of Digoxin Capsules:

Store Digoxin Capsules at 77 degrees F (25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Digoxin Capsules out of the reach of children and away from pets.

General information:

• If you have any questions about Digoxin Capsules, please talk with your doctor, pharmacist, or other health care provider.


• Digoxin Capsules is to be used only by the patient for whom it is prescribed. Do not share it with other people.


• If your symptoms do not improve or if they become worse, check with your doctor.


• Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Digoxin Capsules. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

More Digoxin resources

• Digoxin Dosage
• Digoxin Use in Pregnancy & Breastfeeding
• Drug Images
• Digoxin Drug Interactions
• Digoxin Support Group
• 6 Reviews for Digoxin - Add your own review/rating

Compare Digoxin with other medications

• Atrial Fibrillation
• Heart Failure

difenoxin and atropine

dye-fen-OX-in hye-droe-KLOR-ide, AT-roe-peen SUL-fate

Commonly used brand name(s)

In the U.S.

• Motofen

Available Dosage Forms:

• Tablet

Therapeutic Class: Antidiarrheal

Pharmacologic Class: Atropine

Chemical Class: Difenoxin

Uses For difenoxin and atropine

Difenoxin and atropine combination medicine is used along with other measures to treat severe diarrhea in adults. Difenoxin helps stop diarrhea by slowing down the movements of the intestines.

Since difenoxin is chemically related to some narcotics, it may be habit-forming if taken in doses that are larger than prescribed. To help prevent possible abuse, atropine (an anticholinergic) has been added. If higher-than-normal doses of the combination are taken, the atropine will cause unpleasant effects, making it unlikely that such doses will be taken again.

Difenoxin and atropine combination medicine should not be used in children. Children with diarrhea should be given solutions of carbohydrates (sugars) and electrolytes (important salts) to replace the water and important salts that are lost from the body during diarrhea.

difenoxin and atropine is available only with your doctor's prescription.

Before Using difenoxin and atropine

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For difenoxin and atropine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to difenoxin and atropine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

difenoxin and atropine should not be used in children. Children, especially very young children, are very sensitive to the effects of difenoxin and atropine. This may increase the chance of side effects during treatment. Also, the fluid loss caused by diarrhea may result in a severe condition. For this reason, it is very important that a sufficient amount of liquids be given to replace the fluid lost by the body. If you have any questions about this, check with your health care professional.

Geriatric

Shortness of breath or difficulty in breathing may be more likely to occur in elderly patients, who are usually more sensitive than younger adults to the effects of difenoxin. Also, the fluid loss caused by diarrhea may result in a severe condition. For this reason, elderly persons should not take difenoxin and atropine without first checking with their doctor. It is also very important that a sufficient amount of liquids be taken to replace the fluid lost by the body. If you have any questions about this, check with your health care professional.

Pregnancy

	Pregnancy Category	Explanation
All Trimesters	C	Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking difenoxin and atropine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using difenoxin and atropine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

• Ambenonium


• Potassium

Using difenoxin and atropine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Clorgyline


• Furazolidone


• Iproniazid


• Isocarboxazid


• Moclobemide


• Nialamide


• Pargyline


• Phenelzine


• Procarbazine


• Rasagiline


• Selegiline


• Tapentadol


• Toloxatone


• Tranylcypromine

Using difenoxin and atropine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Arbutamine

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of difenoxin and atropine. Make sure you tell your doctor if you have any other medical problems, especially:

• Alcohol abuse (or history of) or


• Drug abuse (history of)—There is a greater chance that difenoxin and atropine may become habit-forming

• Colitis (severe)—A more serious problem of the colon may develop if you use difenoxin and atropine

• Down's syndrome—Side effects may be more likely and severe in these patients

• Dysentery—This condition may get worse; a different kind of treatment may be needed

• Emphysema, asthma, bronchitis, or other chronic lung disease—There is a greater chance that difenoxin and atropine may cause breathing problems in patients who have any of these conditions

• Enlarged prostate or


• Urinary tract blockage or difficult urination—Problems with urination may develop with the use of difenoxin and atropine

• Gallbladder disease or gallstones—Use of difenoxin and atropine may cause spasms of the biliary tract and make the condition worse

• Glaucoma—Severe pain in the eye may occur with the use of difenoxin and atropine; however, the chance of this happening is low

• Heart disease—difenoxin and atropine may have some effects on the heart, which may make the condition worse

• Hiatal hernia—The atropine in difenoxin and atropine may make this condition worse; however, the chance of this happening is low

• High blood pressure (hypertension)—The atropine in difenoxin and atropine may cause an increase in blood pressure; however, the chance of this happening is low

• Intestinal blockage—difenoxin and atropine may make the condition worse

• Kidney disease—The atropine in difenoxin and atropine may build up in the body and cause side effects

• Liver disease—The chance of central nervous system (CNS) side effects, including coma, may be greater in patients who have this condition

• Myasthenia gravis—difenoxin and atropine may make the condition worse

• Overactive or underactive thyroid—Unwanted effects on breathing and heart rate may occur

• Overflow incontinence—difenoxin and atropine may make the condition worse

Proper Use of difenoxin and atropine

If difenoxin and atropine upsets your stomach, your doctor may want you to take it with food.

Take difenoxin and atropine only as directed by your doctor . Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. If too much is taken, it may become habit-forming.

Importance of diet and fluids while treating diarrhea:

• In addition to using medicine for diarrhea, it is very important that you replace the fluid lost by the body and follow a proper diet. For the first 24 hours you should eat gelatin and drink plenty of caffeine-free clear liquids, such as ginger ale, decaffeinated cola, decaffeinated tea, and broth. During the next 24 hours you may eat bland foods, such as cooked cereals, bread, crackers, and applesauce. Fruits, vegetables, fried or spicy foods, bran, candy, caffeine, and alcoholic beverages may make the condition worse.


• If too much fluid has been lost by the body due to the diarrhea a serious condition may develop. Check with your doctor as soon as possible if any of the following symptoms of too much fluid loss occur:
  
  • Decreased urination
  
  
  • Dizziness and lightheadedness
  
  
  • Dryness of mouth
  
  
  • Increased thirst
  
  
  • Wrinkled skin
  
  

Dosing

The dose of difenoxin and atropine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of difenoxin and atropine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

• For oral dosage form (tablets):
  
  • For severe diarrhea:
    
    • Adults and teenagers—The first dose is usually 2 milligrams (mg). After that, the dose is 1 mg taken after each loose stool or every three or four hours as needed. Do not take more than 8 mg in any twenty-four-hour period.
    
    
    • Children—Use is not recommended.
    
    
  
  

Missed Dose

If you miss a dose of difenoxin and atropine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Precautions While Using difenoxin and atropine

Your doctor should check your progress at regular visits if you will be taking difenoxin and atropine regularly for a long time.

Check with your doctor if your diarrhea does not stop after 2 days or if you develop a fever.

difenoxin and atropine will add to the effects of alcohol and other CNS depressants (medicines that slow down the nervous system, possibly causing drowsiness). Some examples of CNS depressants are antihistamines or medicine for hay fever, other allergies, or colds; sedatives, tranquilizers, or sleeping medicine; prescription pain medicine or narcotics; barbiturates; medicine for seizures; muscle relaxants; or anesthetics, including some dental anesthetics. Check with your doctor before taking any of the above while you are taking difenoxin and atropine.

If you think you or someone else in your home may have taken an overdose of difenoxin and atropine, get emergency help at once. Taking an overdose of difenoxin and atropine may lead to unconsciousness and possibly death. Symptoms of overdose include severe drowsiness; fast heartbeat; shortness of breath or troubled breathing; and unusual warmth, dryness, and flushing of skin.

Before having any kind of surgery (including dental surgery) or emergency treatment, tell the medical doctor or dentist in charge that you are using difenoxin and atropine.

difenoxin and atropine may cause some people to become dizzy, drowsy, or less alert than they are normally. Even if taken at bedtime, it may cause some people to feel drowsy or less alert on arising. Make sure you know how you react to difenoxin and atropine before you drive, use machines, or do anything else that could be dangerous if you are dizzy or are not alert.

difenoxin and atropine Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

• Bloating


• constipation


• loss of appetite


• stomach pain (severe) with nausea and vomiting

Get emergency help immediately if any of the following symptoms of overdose occur:

• Blurred vision (continuing) or changes in near vision


• drowsiness (severe)


• dryness of mouth, nose, and throat (severe)


• fast heartbeat


• shortness of breath or troubled breathing (severe)


• unusual excitement, nervousness, restlessness, or irritability


• unusual warmth, dryness, and flushing of skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common or rare

• Blurred vision


• confusion


• difficult urination


• dizziness or lightheadedness


• drowsiness


• dryness of skin and mouth


• fever


• headache


• trouble in sleeping


• unusual tiredness or weakness

After you stop using difenoxin and atropine, it may still produce some side effects that need attention. During this period of time, check with your doctor immediately if you notice the following side effects:

• Increased sweating


• muscle cramps


• nausea or vomiting


• shivering or trembling


• stomach cramps

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See also: difenoxin and atropine side effects (in more detail)

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More difenoxin and atropine resources

• Difenoxin and atropine Side Effects (in more detail)
• Difenoxin and atropine Use in Pregnancy & Breastfeeding
• Difenoxin and atropine Drug Interactions
• Difenoxin and atropine Support Group
• 2 Reviews for Difenoxin and atropine - Add your own review/rating

Compare difenoxin and atropine with other medications

• Diarrhea, Acute
• Diarrhea, Chronic

Dificid

Generic Name: fidaxomicin (fye DAX oh MYE sin)

Brand Names: Dificid

What is fidaxomicin?

Fidaxomicin is an antibiotic that fights bacteria.

Fidaxomicin is used to treat diarrhea caused by infection with Clostridium difficile.

Fidaxomicin may also be used for purposes not listed in this medication guide.

What is the most important information I should know about fidaxomicin?

You should not use fidaxomicin if you are allergic to it. Take this medication for the full prescribed length of time. Your symptoms may improve before the infection is completely cleared. Skipping doses may also increase your risk of further infection that is resistant to antibiotics. Fidaxomicin should not be used to treat infections that are not related to Clostridium difficile. This medication is for use only to treat diarrhea caused by infection with Clostridium difficile. Fidaxomicin will not treat a viral infection such as the common cold or flu. Call your doctor at once if you have a serious side effect such as fever, chills, flu symptoms, mouth sores, pale skin, feeling light-headed or short of breath, rapid heart rate, trouble concentrating, bloody or tarry stools, or coughing up blood or vomit that looks like coffee grounds.

What should I discuss with my healthcare provider before taking fidaxomicin?

You should not use fidaxomicin if you are allergic to it. Fidaxomicin should not be used to treat infections that are not related to Clostridium difficile. This medication is for use only to treat diarrhea caused by infection with Clostridium difficile. Fidaxomicin will not treat a viral infection such as the common cold or flu. FDA pregnancy category B. Fidaxomicin is not expected to harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. It is not known whether fidaxomicin passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby. Do not give this medication to anyone under 18 years old without medical advice.

How should I take fidaxomicin?

Take exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.

Fidaxomicin is usually taken 2 times each day for 10 days. Follow your doctor's instructions.

You may take fidaxomicin with or without food.

Take this medication for the full prescribed length of time. Your symptoms may improve before the infection is completely cleared. Skipping doses may also increase your risk of further infection that is resistant to antibiotics. Store at room temperature away from moisture and heat.

See also: Dificid dosage (in more detail)

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking fidaxomicin?

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

Fidaxomicin side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have a serious side effect such as:

• 
  

  fever, chills, body aches, flu symptoms, sores in your mouth and throat;

  
  


• 
  

  pale skin, feeling light-headed or short of breath, rapid heart rate, trouble concentrating;

  
  


• 
  

  black, bloody, or tarry stools; or

  
  


• 
  

  coughing up blood or vomit that looks like coffee grounds.

  
  

Less serious side effects may include:

• 
  

  nausea, vomiting, stomach pain;

  
  


• 
  

  bloating or gas; or

  
  


• 
  

  mild rash or itching.

  
  

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect fidaxomicin?

There may be other drugs that can interact with fidaxomicin. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

More Dificid resources

• Dificid Side Effects (in more detail)
• Dificid Dosage
• Dificid Use in Pregnancy & Breastfeeding
• Dificid Drug Interactions
• Dificid Support Group
• 0 Reviews for Dificid - Add your own review/rating

• Dificid Prescribing Information (FDA)


• Dificid Consumer Overview


• Dificid Advanced Consumer (Micromedex) - Includes Dosage Information


• Dificid MedFacts Consumer Leaflet (Wolters Kluwer)


• Fidaxomicin Professional Patient Advice (Wolters Kluwer)

Compare Dificid with other medications

• Clostridial Infection

Where can I get more information?

• Your pharmacist can provide more information about fidaxomicin.

See also: Dificid side effects (in more detail)

Diflucan Suspension

Pronunciation: floo-KON-a-zole
Generic Name: Fluconazole
Brand Name: Diflucan

Diflucan Suspension is used for:

Treating and preventing certain yeast and fungal infections. It may also be used for other conditions as determined by your doctor.

Diflucan Suspension is an azole antifungal. It kills sensitive fungi by interfering with the formation of the fungal cell membrane.

Do NOT use Diflucan Suspension if:

• you are allergic to any ingredient in Diflucan Suspension


• you have certain rare hereditary problems (glucose-galactose malabsorption, fructose intolerance, sucrase-isomaltase deficiency)


• you are taking astemizole, cisapride, clopidogrel, an ergot alkaloid (eg, ergotamine), erythromycin, pimozide, quinidine, terfenadine, or voriconazole

Contact your doctor or health care provider right away if any of these apply to you.

Before using Diflucan Suspension:

Some medical conditions may interact with Diflucan Suspension. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding


• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement


• if you have allergies to medicines, foods, or other substances


• if you have had an allergic reaction to another azole antifungal (eg, itraconazole)


• if you have a history of liver or kidney problems, or heart problems (eg, irregular heartbeat, structural heart problems)


• if you have a weakened immune system, HIV infection, diabetes, cancer, or blood electrolyte problems (eg, low blood potassium or magnesium levels)

Some MEDICINES MAY INTERACT with Diflucan Suspension. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Antiarrhythmics (eg, amiodarone, quinidine, sotalol), arsenic, astemizole, cisapride, domperidone, macrolide antibiotics (eg, erythromycin), pimozide, quinolones (eg, levofloxacin), serotonin (5-HT₁) receptor agonists (eg, eletriptan), terfenadine, or vandetanib because the risk of severe irregular heartbeat (eg, QT prolongation) may be increased


• Rifabutin because the risk of certain eye problems (eg, uveitis) may be increased


• Macrolide immunosuppressants (eg, sirolimus, tacrolimus) because the risk of kidney problems may be increased


• Proton pump inhibitors (PPIs) (eg, omeprazole) or rifamycins (eg, rifampin) because they may decrease Diflucan Suspension's effectiveness


• Clopidogrel, hormonal birth control (eg, birth control pills), or losartan because their effectiveness may be decreased by Diflucan Suspension


• Amphotericin B, anticoagulants (eg, warfarin), benzodiazepines (eg, alprazolam, midazolam), buspirone, certain calcium channel blockers (eg, amlodipine, felodipine, nifedipine), carbamazepine, colchicine, cyclophosphamide, cyclosporine, eplerenone, ergot alkaloids (eg, ergotamine), everolimus, fentanyl, halofantrine, haloperidol, certain HMG-CoA reductase inhibitors or "statins" (eg, atorvastatin, fluvastatin, simvastatin), hydantoins (eg, phenytoin), lurasidone, methadone, muscarinic antagonists (eg, solifenacin, tolterodine), nonsteroidal anti-inflammatory drugs (NSAIDs) (eg, celecoxib, ibuprofen), prednisone, ramelteon, ranolazine, sulfonylureas (eg, glipizide, glyburide, tolbutamide), theophylline, tolvaptan, tretinoin, tricyclic antidepressants (eg, amitriptyline), vinca alkaloids (eg, vinblastine, vincristine), voriconazole, or zidovudine because the risk of their side effects may be increased by Diflucan Suspension

This may not be a complete list of all interactions that may occur. Ask your health care provider if Diflucan Suspension may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Diflucan Suspension:

Use Diflucan Suspension as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Take Diflucan Suspension by mouth with or without food.


• Shake well before each use.


• Use a measuring device marked for medicine dosing. Ask your pharmacist for help if you are unsure of how to measure your dose.


• Take Diflucan Suspension at least 2 hours before taking a PPI (eg, omeprazole).


• To clear up your infection completely, take Diflucan Suspension for the full course of treatment. Keep taking it even if you feel better in a few days. Do not miss any doses.


• Diflucan Suspension works best if it is taken at the same time each day.


• If you miss a dose of Diflucan Suspension, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Diflucan Suspension.

Important safety information:

• Diflucan Suspension may cause dizziness. This effect may be worse if you take it with alcohol or certain medicines. Use Diflucan Suspension with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.


• Diflucan Suspension has been known to cause rare cases of serious liver damage, including death, mainly in patients with serious medical conditions. Liver damage caused by Diflucan Suspension has not been attributed to total daily dose, length of therapy, or sex or age of the patient. This type of liver damage may or may not be reversible when Diflucan Suspension is stopped. Contact your doctor right away if you experience dark urine, loss of appetite, pale stools, severe stomach pain, or yellowing of the skin or eyes.


• If your symptoms do not get better within a few days or if they get worse, check with your doctor.


• Diflucan Suspension only works against fungi; it does not treat viral infections (eg, the common cold) or bacterial infections.


• Tell your doctor or dentist that you take Diflucan Suspension before you receive any medical or dental care, emergency care, or surgery.


• Be sure to use Diflucan Suspension for the full course of treatment. If you do not, the medicine may not clear up your infection completely. The fungus could also become less sensitive to this or other medicines. This could make the infection harder to treat in the future.


• If you develop a rash while you take Diflucan Suspension, contact your doctor.


• Long-term or repeated use of Diflucan Suspension may cause a second infection. Tell your doctor if signs of a second infection occur. Your medicine may need to be changed to treat this.


• Hormonal birth control (eg, birth control pills) may not work as well while you are using Diflucan Suspension. To prevent pregnancy, use an extra form of birth control (eg, condoms).


• Lab tests, including liver and kidney function, may be performed while you use Diflucan Suspension. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.


• Use Diflucan Suspension with caution in the ELDERLY; they may be more sensitive to its effects.


• PREGNANCY and BREAST-FEEDING: Diflucan Suspension may cause harm to the fetus. If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Diflucan Suspension while you are pregnant. Diflucan Suspension is found in breast milk. If you are or will be breast-feeding while you use Diflucan Suspension, check with your doctor. Discuss any possible risks to your baby.

Possible side effects of Diflucan Suspension:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Changes in taste; diarrhea; dizziness; headache; indigestion; mild stomach pain; nausea; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue; unusual hoarseness; wheezing); burning, numbness, or tingling; dark urine; fever, chills, or persistent sore throat; irregular heartbeat; loss of appetite; muscle pain, weakness, or cramping; pale stools; red, swollen, blistered, or peeling skin; seizures; severe or persistent diarrhea, nausea, or vomiting; swelling of the hands; unusual bruising or bleeding; unusual or severe stomach pain; unusual tiredness; yellowing of the eyes or skin.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

See also: Diflucan side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include changes in behavior; hallucinations.

Proper storage of Diflucan Suspension:

Store the unmixed dry powder in the original container, below 86 degrees F (30 degrees C). Store the mixed suspension in the original container, between 41 and 86 degrees F (5 and 30 degrees C), and discard the unused portion after 2 weeks. Do not freeze. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Diflucan Suspension out of the reach of children and away from pets.

General information:

• If you have any questions about Diflucan Suspension, please talk with your doctor, pharmacist, or other health care provider.


• Diflucan Suspension is to be used only by the patient for whom it is prescribed. Do not share it with other people.


• If your symptoms do not improve or if they become worse, check with your doctor.


• Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Diflucan Suspension. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

More Diflucan resources

• Diflucan Side Effects (in more detail)
• Diflucan Use in Pregnancy & Breastfeeding
• Drug Images
• Diflucan Drug Interactions
• Diflucan Support Group
• 26 Reviews for Diflucan - Add your own review/rating

Compare Diflucan with other medications

• Blastomycosis
• Bone Marrow Transplantation
• Candida Infections, Systemic
• Candida Urinary Tract Infection
• Chronic Mucocutaneous Candidiasis
• Coccidioidomycosis
• Coccidioidomycosis, Meningitis
• Cryptococcal Meningitis, Immunocompetent Host
• Cryptococcal Meningitis, Immunosuppressed Host
• Cryptococcosis
• Esophageal Candidiasis
• Fungal Infection Prophylaxis
• Fungal Infection, Internal and Disseminated
• Fungal Peritonitis
• Fungal Pneumonia
• Histoplasmosis
• Onychomycosis, Fingernail
• Onychomycosis, Toenail
• Oral Thrush
• Tinea Versicolor
• Vaginal Yeast Infection

Differin Lotion

Pronunciation: a-DAP-a-leen
Generic Name: Adapalene
Brand Name: Differin

Differin Lotion is used for:

Treating severe acne. It may also be used for other conditions as determined by your doctor.

Differin Lotion is a retinoid-like compound. Exactly how it works is not known. However, it helps the skin cells renew quicker and decreases blackhead formation.

Do NOT use Differin Lotion if:

• you are allergic to any ingredient in Differin Lotion

Contact your doctor or health care provider right away if any of these apply to you.

Before using Differin Lotion:

Some medical conditions may interact with Differin Lotion. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding


• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement


• if you have allergies to medicines, foods, or other substances


• if you have eczema or sunburn

Some MEDICINES MAY INTERACT with Differin Lotion. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Products that contain resorcinol, salicylic acid, or sulfur because the risk of skin irritation may be increased

Ask your health care provider if Differin Lotion may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Differin Lotion:

Use Differin Lotion as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Differin Lotion is for external use only. Avoid contact with the eyes, lips, angles of the nose, and mucous membranes. Exposure of Differin Lotion to the eye may cause swelling, redness, and irritation.


• Do not apply Differin Lotion to cuts, damaged or sunburned skin, or eczema.


• Use Differin Lotion in the evening before bedtime unless directed otherwise by your doctor.


• Before applying Differin Lotion, clean the area to be treated with mild soap or soapless cleanser and gently dry.


• Apply a thin film of Differin Lotion to the entire face and other affected areas, as directed by your doctor. Use an amount about the size of a nickel (3 to 4 pumps) to cover the entire face. Rub in gently. Wash your hands immediately after using Differin Lotion.


• A mild sensation of warmth or slight stinging may occur shortly after using Differin Lotion.


• If you miss a dose of Differin Lotion, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once. If several applications are missed, contact your doctor or pharmacist.

Ask your health care provider any questions you may have about how to use Differin Lotion.

Important safety information:

• Differin Lotion may cause you to become sunburned more easily. Avoid the sun, sunlamps, or tanning booths until you know how you react to Differin Lotion. Use a sunscreen or wear protective clothing if you must be outside for more than a short time.


• Do not use more than the recommended dose or more often than prescribed without checking with your doctor. Doing so will not make Differin Lotion work faster or better, but may increase the risk of skin irritation.


• Acne may worsen temporarily when you begin using Differin Lotion. This is normal and not a cause for concern. Continue to use Differin Lotion. If your condition does not improve within 12 weeks, check with your doctor.


• Do not use other medicines or skin products on the affected area without first checking with your doctor. Some other products may increase the risk of skin irritation.


• Skin moisturizers may be used if necessary. Do not use moisturizers that contain alpha hydroxy or glycolic acids.


• Certain cosmetic procedures, such as waxing, should not be performed on treated skin because of possible irritation.


• Cosmetics may be used while using Differin Lotion. After using cosmetics, thoroughly wash and dry the affected area before applying Differin Lotion.


• Wind and cold temperatures can also irritate the affected skin.


• Differin Lotion should be used with extreme caution in CHILDREN younger than 12 years old; safety and effectiveness in these children have not been confirmed.


• PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Differin Lotion while you are pregnant. It is not known if Differin Lotion is found in breast milk. If you are or will be breast-feeding while you use Differin Lotion, check with your doctor. Discuss any possible risks to your baby.

Possible side effects of Differin Lotion:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Dry skin; feeling of warmth; irritation; itching; peeling; redness; scaling; temporary burning and stinging.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); blistering; crusting; excessive redness or peeling; swelling.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

See also: Differin side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Differin Lotion may be harmful if swallowed.

Proper storage of Differin Lotion:

Store Differin Lotion at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat and light. Do not freeze or refrigerate. Keep Differin Lotion out of the reach of children and away from pets.

General information:

• If you have any questions about Differin Lotion, please talk with your doctor, pharmacist, or other health care provider.


• Differin Lotion is to be used only by the patient for whom it is prescribed. Do not share it with other people.


• If your symptoms do not improve or if they become worse, check with your doctor.


• Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Differin Lotion. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

More Differin resources

• Differin Side Effects (in more detail)
• Differin Use in Pregnancy & Breastfeeding
• Differin Drug Interactions
• Differin Support Group
• 14 Reviews for Differin - Add your own review/rating

Compare Differin with other medications

• Acne

dihydrocodeine and guaifenesin

Generic Name: dihydrocodeine and guaifenesin (dye HYE droe KOE deen gwye FEN e sin)

Brand Names: J-Max DHC

What is dihydrocodeine and guaifenesin?

Dihydrocodeine is a narcotic cough suppressant. It affects signals in the brain that trigger the cough reflex.

Guaifenesin is an expectorant. It helps loosen congestion in your chest and throat, making it easier to cough out through your mouth.

The combination of dihydrocodeine and guaifenesin is used to treat cough and to reduce chest congestion caused by allergies, flu, or the common cold.

Dihydrocodeine and guaifenesin will not treat a cough that is caused by smoking, asthma, or emphysema.

Dihydrocodeine and guaifenesin may also be used for other purposes not listed in this medication guide.

What is the most important information I should know about dihydrocodeine and guaifenesin?

Always ask a doctor before giving a cough or cold medicine to a child. Death can occur from the misuse of cough and cold medicines in very young children. Do not take this medication if you have taken furazolidone (Furoxone), sodium oxybate (GHB, Xyrem), or an MAO inhibitor such as isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam), or tranylcypromine (Parnate) within the past 14 days. Serious or life-threatening side effects can occur if you take dihydrocodeine and guaifenesin before these other medications have cleared from your body. You also should not take dihydrocodeine and guaifenesin if you have severe high blood pressure, ischemic heart disease, stomach ulcer, blocked intestines, urination problems, narrow angle glaucoma, or if you are having an asthma attack or are allergic to other narcotic medications (Lortab, Vicodin, OxyContin, Demerol, and others). Do not take dihydrocodeine and guaifenesin with alcohol, other narcotic pain medications, sedatives, tranquilizers, muscle relaxers, or other medicines that can make you sleepy or slow your breathing. Dangerous side effects may result. Dihydrocodeine may be habit-forming and should be used only by the person it was prescribed for. Dihydrocodeine should never be shared with another person, especially someone who has a history of drug abuse or addiction. Keep the medication in a secure place where others cannot get to it.

What should I discuss with my healthcare provider before taking dihydrocodeine and guaifenesin?

Do not take this medication if you have taken furazolidone (Furoxone), sodium oxybate (GHB, Xyrem), or an MAO inhibitor such as isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam), or tranylcypromine (Parnate) within the past 14 days. Serious or life-threatening side effects can occur if you take dihydrocodeine and guaifenesin before these other medications have cleared from your body. You should not use this medication if you are allergic to dihydrocodeine or guaifenesin, or if you have:

• 
  

  severe or uncontrolled high blood pressure;

  
  


• 
  

  ischemic heart disease (reduced circulation of blood to the heart);

  
  


• 
  

  stomach ulcer;

  
  


• 
  

  a blockage in your intestines;

  
  


• 
  

  urination problems;

  
  


• 
  

  narrow angle glaucoma;

  
  


• 
  

  if you are having an asthma attack; or

  
  


• 
  

  if you are allergic to other narcotic medications such as codeine (Tylenol 3), hydrocodone (Lortab, Vicodin), hydromorphone (Dilaudid, Palladone), meperidine (Demerol), morphine (Kadian, MS Contin, Oramorph), oxycodone (OxyContin), and others.

  
  

If you have any of these other conditions, you may need a dose adjustment or special tests to safely take dihydrocodeine and guaifenesin:

• 
  

  heart disease, high or low blood pressure;

  
  


• 
  

  circulation problems or a history of stroke;

  
  


• 
  

  asthma, COPD, emphysema, or other breathing disorders;

  
  


• kidney or liver disease;


• 
  

  a history of head injury or brain tumor;

  
  


• 
  

  epilepsy or other seizure disorder;

  
  


• 
  

  diabetes;

  
  


• 
  

  a gallbladder or pancreas problem;

  
  


• 
  

  a thyroid disorder;

  
  


• 
  

  glaucoma;

  
  


• 
  

  enlarged prostate, urination problems;

  
  


• 
  

  Addison's disease or other adrenal gland disorders;

  
  


• 
  

  a history of stomach problems such as ulcers, intestinal blockage, ulcerative colitis, or any surgeries; or

  
  


• 
  

  a history of drug or alcohol addiction, or suicidal thoughts.

  
  

FDA pregnancy category C. It is not known whether dihydrocodeine and guaifenesin is harmful to an unborn baby. Before taking this medication, tell your doctor if you are pregnant or plan to become pregnant during treatment. It is not known whether dihydrocodeine and guaifenesin passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby. Dihydrocodeine may be habit-forming and should be used only by the person it was prescribed for. Dihydrocodeine should never be shared with another person, especially someone who has a history of drug abuse or addiction. Keep the medication in a secure place where others cannot get to it. Dihydrocodeine is a drug of abuse and you should be aware if any person in the household is using this medicine improperly or without a prescription. Older adults may be more likely to have side effects from this medication.

How should I take dihydrocodeine and guaifenesin?

Take this medication exactly as it has been prescribed by your doctor. Do not use the medication in larger amounts, or use it for longer than recommended. Cough or cold medicine is usually taken only for a short time until your symptoms clear up.

Always ask a doctor before giving cough or cold medicine to a child. Death can occur from the misuse of cough or cold medicine in very young children.

You may take this medication with or without food.

Drink extra fluids to help loosen the congestion and lubricate your throat while you are taking this medication.

Measure the liquid form of this medicine with a special dose-measuring spoon or cup, not a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist for one.

Take dihydrocodeine and guaifenesin with food if it upsets your stomach. Talk with your doctor if your symptoms do not improve after 7 days of treatment, or if you have a fever with a headache, cough, or skin rash.

This medication can cause you to have unusual results with allergy skin tests. Tell any doctor who treats you that you are taking an antihistamine.

If you need to have any type of surgery, tell the surgeon ahead of time if you have taken a cold medicine within the past few days.

Store this medicine at room temperature, away from heat, light, and moisture.

See also: Dihydrocodeine and guaifenesin dosage (in more detail)

What happens if I miss a dose?

Cough or cold medicine is usually taken only as needed, so you may not be on a dosing schedule. If you are taking the medication regularly, take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the medicine at your next regularly scheduled time. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention if you think you have used too much of this medicine. An overdose of dihydrocodeine can be fatal.

Overdose symptoms may include vomiting, extreme dizziness or drowsiness, confusion, hallucinations, blurred vision, cold and clammy skin, fast/slow or uneven heart rate, pinpoint pupils, fainting, and seizure (convulsions).

What should I avoid while taking dihydrocodeine and guaifenesin?

Avoid drinking alcohol while you are taking this medication. Alcohol can increase some of the side effects of dihydrocodeine. Dihydrocodeine and guaifenesin can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert.

Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Get up slowly and steady yourself to prevent a fall.

Do not use any other over-the-counter cold, allergy, or cough medicine without first asking your doctor or pharmacist. Guaifenesin is contained in many medicines available over the counter. If you take certain products together you may accidentally take too much of a certain drug. Read the label of any other medicine you are using to see if it contains guaifenesin.

Avoid becoming overheated or dehydrated during exercise and in hot weather.

Dihydrocodeine and guaifenesin side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop taking this medication and call your doctor at once if you have any of these serious side effects:

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  fast or uneven heart rate;

  
  


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  feeling like you might pass out;

  
  


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  confusion, hallucinations, unusual thoughts or behavior;

  
  


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  severe dizziness or drowsiness, feeling irritable;

  
  


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  shallow breathing, slow heartbeat;

  
  


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  painful or difficult urination; or

  
  


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  seizure (convulsions).

  
  

Less serious side effects may include:

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  dizziness, drowsiness, headache;

  
  


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  constipation;

  
  


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  increased sweating;

  
  


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  nausea, vomiting, upset stomach, mild loss of appetite;

  
  


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  feeling excited or restless;

  
  


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  sleep problems (insomnia);

  
  


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  warmth, tingling, or redness under your skin; or

  
  


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  skin rash or itching.

  
  

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Dihydrocodeine and guaifenesin Dosing Information

Usual Adult Dose for Cough and Nasal Congestion:

Dihydrocodeine-guaifenesin 7.5 mg-100 mg/5 mL oral liquid:
5 to 10 mL orally every 4 to 6 hours.

Usual Pediatric Dose for Cough and Nasal Congestion:

Dihydrocodeine-guaifenesin 7.5 mg-100 mg/5 mL oral liquid:
6 to 11 years: 2.5 to 5 mL orally every 4 to 6 hours.
12 years or older: 5 to 10 mL orally every 4 to 6 hours.

What other drugs will affect dihydrocodeine and guaifenesin?

Do not take this medication with alcohol, other narcotic pain medications, sedatives, tranquilizers, muscle relaxers, or other medicines that can make you sleepy or slow your breathing. Dangerous side effects may result.

Tell your doctor about all other medicines you take, especially:

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  cimetidine (Tagamet);

  
  


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  methyldopa (Aldomet);

  
  


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  mecamylamine (Inversine);

  
  


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  a beta-blocker such as atenolol (Tenormin), carvedilol (Coreg), esmolol (Brevibloc), labetalol (Normodyne, Trandate), metoprolol (Lopressor, Toprol), nadolol (Corgard), propranolol (Inderal, InnoPran), sotalol (Betapace), and others;

  
  


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  HIV or AIDS medicine such as atazanavir (Reyataz), darunavir (Prezista), delavirdine (Rescriptor), fosamprenavir (Lexiva), indinavir (Crixivan), nelfinavir (Viracept), ritonavir (Norvir), or saquinavir (Invirase, Fortovase); or

  
  


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  phenothiazines such as chlorpromazine (Thorazine), fluphenazine (Prolixin), perphenazine (Trilafon), prochlorperazine (Compazine), promethazine (Phenergan, Adgan, Anergan 50, Pentazine), thioridazine (Mellaril), or trifluperazine (Stelazine).

  
  

This list is not complete and there may be other drugs that can interact with dihydrocodeine and guaifenesin. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

More dihydrocodeine and guaifenesin resources

• Dihydrocodeine and guaifenesin Side Effects (in more detail)
• Dihydrocodeine and guaifenesin Dosage
• Dihydrocodeine and guaifenesin Use in Pregnancy & Breastfeeding
• Dihydrocodeine and guaifenesin Drug Interactions
• Dihydrocodeine and guaifenesin Support Group
• 0 Reviews for Dihydrocodeine and guaifenesin - Add your own review/rating

Compare dihydrocodeine and guaifenesin with other medications

• Cough
• Cough and Nasal Congestion

Where can I get more information?

• Your pharmacist can provide more information about dihydrocodeine and guaifenesin.

See also: dihydrocodeine and guaifenesin side effects (in more detail)